Lebrin Franck

Lebrin Franck

Research officer at INSERM
Associate Professor in the Einthoven Laboratory at Leiden University Medical Center
ORCID: 0000-0002-1650-6757
See ResearchGate profile >


  • 2014 – “Habilitation à Diriger des Recherches”, Université Pierre et Marie Curie, Paris, France
  • 2000 – PhD in Biology, University of Grenoble I, France
    “Role of protein kinase CK2 in cell proliferation”
  • 1995 – Master in Cell Biology and Physiology, University of Grenoble I, France

Professional experience

  • since 2016 – Associate professor in Vascular Nephrology, Group leader in Internal Medicine, Leiden University Medical Center, The Netherlands
  • since 2005 – Tenured research officer at INSERM, Paris, France
  • 2013-2015 – Group leader at Collège de France, Paris, France
  • 2001-2004 – Postdoctoral researcher in the Netherlands Cancer Institute, Amsterdam
  • 2004-2005 – Postdoctoral researcher in the Hubrecht Institute, Utrecht, The Netherlands

Main awards and distinctions

  • 2010 – Delheim Prize of the Collège de France

Research topics

  • vascular biology
  • hereditary hemorrhagic telangiectasia
  • neurological disorders
  • cancer
  • drug discovery
  • preclinical models for drug testing and in vivo imaging

Main publications

  • Thalgott JH, Dos-santos-Luis D, Hosman AE, Martin S, Lamandé N, Barcquart D, Srun S, Galaris G, De Boer HC, Tual-Chabot S, Kroon S, Arthur HM, Cao Y, Snijder RJ, Disch F, Mager JJ, Rabelink TJ, Mummery CL, Lebrin F. Decreased expression of VEGFR1 contributes to the pathogenesis of Hereditary Hemorrhagic Telangiectasia type 2. Circulation (2018) doi:10.1161/CIRCULATIONAHA.117.033062
  • Lebrin F, Srun S, Raymond K, Martin S, van den Brink S, Freitas C, Bréant C, Mathivet T, Larrivée B, Thomas JL, Arthur HM, Westermann CJ, Disch F, Mager JJ, Snijder RJ, Eichmann A, Mummery CL. Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia. Nature Medicine (2010) 16:420-8. doi:10.1038/nm.2131
  • Van Laake LW, van den Driesche S, Post S, Feijen A, Jansen MA, Driessens MH, Mager JJ, Snijder RJ, Westermann CJ, Doevendans PA, van Echteld CJ, ten Dijke P, Arthur HM, Goumans MJ, Lebrin F*, Mummery CL*. Endoglin has a crucial role in blood cell-mediated vascular repair. Circulation (2006) 114: 2288-97. doi: 10.1161/CIRCULATIONAHA.106.639161
  • Lebrin F, Goumans MJ, Jonker L, Carvalho RL, Valdimarsdottir G, Thorikay M, Mummery C, Arthur HM, ten Dijke P. Endoglin promotes endothelial cell proliferation and TGF-β/ALK1 signal transduction. EMBO J. (2004) 23(20): 4018-28. doi:10.1038/sj.emboj.7600386
  • International Stem Cell Initiative. Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat Biotechnol. (2007) 25(7): 803-16. doi:10.1038/nbt1318
  • Hériché JK, Lebrin F, Rabilloud T, Leroy D, Chambaz EM, Goldberg Y. Regulation of protein phosphatase 2A by direct interaction with casein kinase 2a. Science (1997) 276: 952-5. doi:10.1126/science.276.5314.952

Latest publications

  • Thalgott JH, Dos-Santos-Luis D, Hosman AE, Martin S, Lamandé N, Bracquart D, Srun S, Galaris G, de Boer HC, Tual-Chalot S, Kroon S, Arthur HM, Cao Y, Snijder RJ, Disch F, Mager JJ, Rabelink TJ, Mummery CL, Raymond K, Lebrin F. Decreased expression of vascular endothelial growth factor receptor 1 contributes to the pathogenesis of hereditary hemorrhagic telangiectasia type 2. Circulation (2018) 138(23):2698-712. doi:10.1161/CIRCULATIONAHA.117.033062
  • Lempereur A, Canto PY, Richard C, Martin S, Thalgott J, Raymond K, Lebrin F, Drevon C, Jaffredo T. The TGFβ pathway is a key player for the endothelial-to-hematopoietic transition in the embryonic aorta. Dev Biol (2018) 434(2):292-303. doi:10.1016/j.ydbio.2017.12.006
  • Acuna-Mendoza S, Martin S, Kuchler-Bopp S, Ribes S, Thalgott J, Chaussain C, Creuzet S, Lesot H, Lebrin F, Poliard A. A new Wnt1-CRE TomatoRosa embryonic stem cell line: A tool for studying neural crest cell integration capacity. Stem Cells Dev (2017) 26(23):1682-94. doi:10.1089/scd.2017.0115
  • Gkatzis K, Thalgott J, Dos-Santos-Luis D, Martin S, Lamandé N, Carette MF, Disch F, Snijder RJ, Westermann CJ, Mager JJ, Oh SP, Miquerol L, Arthur HM, Mummery CL, Lebrin F. Interaction between ALK1 signaling and Connexin40 in the development of arteriovenous malformations. Arterioscler Thromb Vasc Biol (2016) 36(4):707-17. doi:10.1161/ATVBAHA.115.306719
  • Thalgott J, Dos-Santos-Luis D, Lebrin F. Pericytes as targets in hereditary hemorrhagic telangiectasia. Front Genet (2015) 5: doi:10.3389/fgene.2015.00037