2014 – “Habilitation à Diriger des Recherches”, Université Pierre et Marie Curie, Paris, France
2000 – PhD in Biology, University of Grenoble I, France “Role of protein kinase CK2 in cell proliferation”
1995 – Master in Cell Biology and Physiology, University of Grenoble I, France
Professional experience
since 2016 – Associate professor in Vascular Nephrology, Group leader in Internal Medicine, Leiden University Medical Center, The Netherlands
since 2005 – Tenured research officer at INSERM, Paris, France
2013-2015 – Group leader at Collège de France, Paris, France
2001-2004 – Postdoctoral researcher in the Netherlands Cancer Institute, Amsterdam
2004-2005 – Postdoctoral researcher in the Hubrecht Institute, Utrecht, The Netherlands
Main awards and distinctions
2010 – Delheim Prize of the Collège de France
Research topics
vascular biology
hereditary hemorrhagic telangiectasia
neurological disorders
cancer
drug discovery
preclinical models for drug testing and in vivo imaging
Main publications
Thalgott JH, Dos-santos-Luis D, Hosman AE, Martin S, Lamandé N, Barcquart D, Srun S, Galaris G, De Boer HC, Tual-Chabot S, Kroon S, Arthur HM, Cao Y, Snijder RJ, Disch F, Mager JJ, Rabelink TJ, Mummery CL, Lebrin F. Decreased expression of VEGFR1 contributes to the pathogenesis of Hereditary Hemorrhagic Telangiectasia type 2. Circulation (2018) doi:10.1161/CIRCULATIONAHA.117.033062
Lebrin F, Srun S, Raymond K, Martin S, van den Brink S, Freitas C, Bréant C, Mathivet T, Larrivée B, Thomas JL, Arthur HM, Westermann CJ, Disch F, Mager JJ, Snijder RJ, Eichmann A, Mummery CL. Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia. Nature Medicine (2010) 16:420-8. doi:10.1038/nm.2131
Van Laake LW, van den Driesche S, Post S, Feijen A, Jansen MA, Driessens MH, Mager JJ, Snijder RJ, Westermann CJ, Doevendans PA, van Echteld CJ, ten Dijke P, Arthur HM, Goumans MJ, Lebrin F*, Mummery CL*. Endoglin has a crucial role in blood cell-mediated vascular repair. Circulation (2006) 114: 2288-97. doi: 10.1161/CIRCULATIONAHA.106.639161
Lebrin F, Goumans MJ, Jonker L, Carvalho RL, Valdimarsdottir G, Thorikay M, Mummery C, Arthur HM, ten Dijke P. Endoglin promotes endothelial cell proliferation and TGF-β/ALK1 signal transduction. EMBO J. (2004) 23(20): 4018-28. doi:10.1038/sj.emboj.7600386
International Stem Cell Initiative. Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat Biotechnol. (2007) 25(7): 803-16. doi:10.1038/nbt1318
Hériché JK, Lebrin F, Rabilloud T, Leroy D, Chambaz EM, Goldberg Y. Regulation of protein phosphatase 2A by direct interaction with casein kinase 2a. Science (1997) 276: 952-5. doi:10.1126/science.276.5314.952
Latest publications
Thalgott JH, Dos-Santos-Luis D, Hosman AE, Martin S, Lamandé N, Bracquart D, Srun S, Galaris G, de Boer HC, Tual-Chalot S, Kroon S, Arthur HM, Cao Y, Snijder RJ, Disch F, Mager JJ, Rabelink TJ, Mummery CL, Raymond K, Lebrin F. Decreased expression of vascular endothelial growth factor receptor 1 contributes to the pathogenesis of hereditary hemorrhagic telangiectasia type 2. Circulation (2018) 138(23):2698-712. doi:10.1161/CIRCULATIONAHA.117.033062
Lempereur A, Canto PY, Richard C, Martin S, Thalgott J, Raymond K, Lebrin F, Drevon C, Jaffredo T. The TGFβ pathway is a key player for the endothelial-to-hematopoietic transition in the embryonic aorta. Dev Biol (2018) 434(2):292-303. doi:10.1016/j.ydbio.2017.12.006
Acuna-Mendoza S, Martin S, Kuchler-Bopp S, Ribes S, Thalgott J, Chaussain C, Creuzet S, Lesot H, Lebrin F, Poliard A. A new Wnt1-CRE TomatoRosa embryonic stem cell line: A tool for studying neural crest cell integration capacity. Stem Cells Dev (2017) 26(23):1682-94. doi:10.1089/scd.2017.0115
Gkatzis K, Thalgott J, Dos-Santos-Luis D, Martin S, Lamandé N, Carette MF, Disch F, Snijder RJ, Westermann CJ, Mager JJ, Oh SP, Miquerol L, Arthur HM, Mummery CL, Lebrin F. Interaction between ALK1 signaling and Connexin40 in the development of arteriovenous malformations. Arterioscler Thromb Vasc Biol (2016) 36(4):707-17. doi:10.1161/ATVBAHA.115.306719
Thalgott J, Dos-Santos-Luis D, Lebrin F. Pericytes as targets in hereditary hemorrhagic telangiectasia. Front Genet (2015) 5: doi:10.3389/fgene.2015.00037
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