ESPCI web site
Pham Linh-Giang
PhD student
linh-giang.pham@espci.fr
Research topic
Multiparametric ultrasound imaging
Supervisor
Latest Publications
4989618
94NJIV78
Pham
1
national-institute-of-health-research
5
date
desc
9078
https://blog.espci.fr/physmed/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22W55EQ9GN%22%2C%22library%22%3A%7B%22id%22%3A4989618%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A11283997%2C%22username%22%3A%22Justine_Robin_PhysMed%22%2C%22name%22%3A%22%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Fjustine_robin_physmed%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Rideau%20Batista%20Novais%20et%20al.%22%2C%22parsedDate%22%3A%222016%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BRideau%20Batista%20Novais%20A%2C%20Pham%20H%2C%20Van%20de%20Looij%20Y%2C%20Bernal%20M%2C%20Mairesse%20J%2C%20Zana-Taieb%20E%2C%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20Transcriptomic%20regulations%20in%20oligodendroglial%20and%20microglial%20cells%20related%20to%20brain%20damage%20following%20fetal%20growth%20restriction.%20%26lt%3Bi%26gt%3BGlia%26lt%3B%5C%2Fi%26gt%3B%202016%3B%26lt%3Bb%26gt%3B64%26lt%3B%5C%2Fb%26gt%3B%3A2306%26%23x2013%3B20.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fglia.23079%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fglia.23079%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Transcriptomic%20regulations%20in%20oligodendroglial%20and%20microglial%20cells%20related%20to%20brain%20damage%20following%20fetal%20growth%20restriction%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aline%22%2C%22lastName%22%3A%22Rideau%20Batista%20Novais%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hoa%22%2C%22lastName%22%3A%22Pham%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yohan%22%2C%22lastName%22%3A%22Van%20de%20Looij%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miguel%22%2C%22lastName%22%3A%22Bernal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jerome%22%2C%22lastName%22%3A%22Mairesse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elodie%22%2C%22lastName%22%3A%22Zana-Taieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marina%22%2C%22lastName%22%3A%22Colella%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre-Henri%22%2C%22lastName%22%3A%22Jarreau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Pansiot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florent%22%2C%22lastName%22%3A%22Dumont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phane%22%2C%22lastName%22%3A%22Sizonenko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Gressens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christiane%22%2C%22lastName%22%3A%22Charriaut-Marlangue%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mickael%22%2C%22lastName%22%3A%22Tanter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charlie%22%2C%22lastName%22%3A%22Demene%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Vaiman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Baud%22%7D%5D%2C%22abstractNote%22%3A%22Fetal%20growth%20restriction%20%28FGR%29%20is%20a%20major%20complication%20of%20human%20pregnancy%2C%20frequently%20resulting%20from%20placental%20vascular%20diseases%20and%20prenatal%20malnutrition%2C%20and%20is%20associated%20with%20adverse%20neurocognitive%20outcomes%20throughout%20life.%20However%2C%20the%20mechanisms%20linking%20poor%20fetal%20growth%20and%20neurocognitive%20impairment%20are%20unclear.%20Here%2C%20we%20aimed%20to%20correlate%20changes%20in%20gene%20expression%20induced%20by%20FGR%20in%20rats%20and%20abnormal%20cerebral%20white%20matter%20maturation%2C%20brain%20microstructure%2C%20and%20cortical%20connectivity%20in%20vivo.%20We%20investigated%20a%20model%20of%20FGR%20induced%20by%20low-protein-diet%20malnutrition%20between%20embryonic%20day%200%20and%20birth%20using%20an%20interdisciplinary%20approach%20combining%20advanced%20brain%20imaging%2C%20in%20vivo%20connectivity%2C%20microarray%20analysis%20of%20sorted%20oligodendroglial%20and%20microglial%20cells%20and%20histology.%20We%20show%20that%20myelination%20and%20brain%20function%20are%20both%20significantly%20altered%20in%20our%20model%20of%20FGR.%20These%20alterations%2C%20detected%20first%20in%20the%20white%20matter%20on%20magnetic%20resonance%20imaging%20significantly%20reduced%20cortical%20connectivity%20as%20assessed%20by%20ultrafast%20ultrasound%20imaging.%20Fetal%20growth%20retardation%20was%20found%20associated%20with%20white%20matter%20dysmaturation%20as%20shown%20by%20the%20immunohistochemical%20profiles%20and%20microarrays%20analyses.%20Strikingly%2C%20transcriptomic%20and%20gene%20network%20analyses%20reveal%20not%20only%20a%20myelination%20deficit%20in%20growth-restricted%20pups%2C%20but%20also%20the%20extensive%20deregulation%20of%20genes%20controlling%20neuroinflammation%20and%20the%20cell%20cycle%20in%20both%20oligodendrocytes%20and%20microglia.%20Our%20findings%20shed%20new%20light%20on%20the%20cellular%20and%20gene%20regulatory%20mechanisms%20mediating%20brain%20structural%20and%20functional%20defects%20in%20malnutrition-induced%20FGR%2C%20and%20suggest%2C%20for%20the%20first%20time%2C%20a%20neuroinflammatory%20basis%20for%20the%20poor%20neurocognitive%20outcome%20observed%20in%20growth-restricted%20human%20infants.%20GLIA%202016%3B64%3A2306%5Cu20132320%22%2C%22date%22%3A%222016%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1002%5C%2Fglia.23079%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1002%5C%2Fglia.23079%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221098-1136%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%2294NJIV78%22%5D%2C%22dateModified%22%3A%222023-04-07T13%3A35%3A26Z%22%7D%7D%5D%7D
1
Rideau Batista Novais A, Pham H, Van de Looij Y, Bernal M, Mairesse J, Zana-Taieb E, et al. Transcriptomic regulations in oligodendroglial and microglial cells related to brain damage following fetal growth restriction. Glia 2016;64:2306–20. https://doi.org/10.1002/glia.23079.
