Pernot Mathieu

Pernot Mathieu

Deputy director of Physics for Medicine Paris
Research director at Inserm
ResearcherID: G-3404-2013
ORCID: 0000-0001-6713-4642
See the ResearchGate profile >


  • 2015 – “Habilitation à Diriger des Recherches”, Université Paris Diderot, France
  • 2004 – PhD in Physics, Université Paris Diderot, France
    “Ultrasound therapy and monitoring: new techniques”
  • 2001 – Master of Science in Acoustics, Université Paris Diderot, France
  • 2001 – Engineering degree at ESPCI (Ecole Supérieure de Physique et Chimie Industrielles), Paris, France

Professional experience

  • since 2019 – Deputy director of Physics for Medicine Paris laboratory, Paris, France
  • since 2016 – Tenured research director, Inserm, Paris, France
  • 2016 – Co-founder of the company Iconeus
  • 2014 – Co-founder of the company Cardiawave
  • 2007-2016 – Tenured research officer, Inserm, Paris, France

Main awards and distinctions

  • 2016 Outstanding Paper Award of the IEEE Transactions in Ultrasonics, Ferroelectrics and Frequency Control
  • 2015 Béatrice Denys Award of the French Foundation for therapeutic innovation
  • Winner of the BPI ILab Competition for the creation of innovative technology companies in 2014 (project Valvopulse) and 2015 (project Neuroflow)
  • Winner of the Concours Mondial de l’Innovation, phase I, II & III (project Valvosoft)
  • ERC Starting Grant 2012 (project ULTRAECHOCARDIO)

Research topics

  • Cardiovascular applications of ultrasound
  • Ultrafast ultrasound imaging of the cardiovascular system
  • 3D ultrafast ultrasound imaging
  • Non-invasive cardiac therapy

Main publications

Demeulenaere O, Bertolo A, Pezet S, Ialy-Radio N, Osmanski B, Papadacci C, et al. In vivo whole brain microvascular imaging in mice using transcranial 3D Ultrasound Localization Microscopy. EBioMedicine 2022;79:12. ebiom.2022.103995.
Demeulenaere O, Sandoval Z, Mateo P, Dizeux A, Villemain O, Gallet R, et al. Coronary Flow Assessment Using 3-Dimensional Ultrafast Ultrasound Localization Microscopy. JACC: Cardiovascular Imaging 2022:16.
Demené C, Robin J, Dizeux A, Heiles B, Pernot M, Tanter M, et al. Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patients. Nat Biomed Eng 2021;5:219–28.
Pedreira O, Correia M, Chatelin S, Villemain O, Goudot G, Thiebaut S, et al. Smart ultrasound device for non-invasive real-time myocardial stiffness quantification of the human heart. IEEE Transactions on Biomedical Engineering 2021:1–1.
Messas E, Rémond MC, Goudot G, Zarka S, Penot R, Mateo P, et al. Feasibility and safety of non-invasive ultrasound therapy (NIUT) on porcine aortic valve. Phys Med Biol 2020.
Rabut C, Correia M, Finel V, Pezet S, Pernot M, Deffieux T, et al. 4D functional ultrasound imaging of whole-brain activity in rodents. Nat Methods 2019:1–4.
Provost J, Garofalakis A, Sourdon J, Bouda D, Berthon B, Viel T, et al. Simultaneous positron emission tomography and ultrafast ultrasound for hybrid molecular, anatomical and functional imaging. NATURE BIOMEDICAL ENGINEERING 2018;2:85–94.

Latest publications

Goudot G, Jimenez A, Mohamedi N, Sitruk J, Wang LZ, Khider L, et al. Vasa vasorum interna in the carotid wall of active forms of Takayasu arteritis evidenced by ultrasound localization microscopy. Vasc Med 2024:1358863X241228262.
Khider L, Goudot G, Messas E, Pernot M. Ultrasons dans le traitement des thromboses veineuses. JMV-Journal de Médecine Vasculaire 2024;49:38.
Baudo M, Magrini E, Pernot M, Sicouri S, Torregrossa G, Beurton A, et al. Hydrophilic polymer embolization after TAVI. Journal of Cardiology 2024;0:
Malik A, Villalobos LJC, Baranger J, Venet M, Pernot M, Mital S, et al. Comparison Between Acoustic Radiation Force-Induced and Natural Wave Velocities for Myocardial Stiffness Assessment in Hypertrophic Cardiomyopathy. JACC: Cardiovascular Imaging 2024;17:223–5.
Raboudi A, Hervé P-Y, Allanic M, Boutinaud P, Christophe J-J, Firat H, et al. The PACIFIC ontology for heterogeneous data management in cardiology. Journal of Biomedical Informatics 2024;149:104579.
Caenen A, Bézy S, Pernot M, Nightingale KR, Vos HJ, Voigt J-U, et al. Ultrasound Shear Wave Elastography in Cardiology. JACC: Cardiovascular Imaging 2024;17:314–29.