
Ge Zhang
Postdoc
ge.zhang@espci.fr
Research topic
Gas vesicles for ultrasound imaging
Supervisor
Latest Publications with our group
4989618
94NJIV78
Zhang
1
national-institute-of-health-research
5
date
desc
7492
https://blog.espci.fr/physmed/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22D3BTJF99%22%2C%22library%22%3A%7B%22id%22%3A4989618%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zhang%20et%20al.%22%2C%22parsedDate%22%3A%222026-01-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BZhang%20G%2C%20Leroy%20H%2C%20Haidour%20N%2C%20Zucker%20N%2C%20Rivera%20DE%2C%20Jimenez%20A%2C%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20Exploiting%20harmonic%20signature%20of%20gas%20vesicles%20in%20amplitude-modulated%20singular%20value%20decomposition%20for%20ultrafast%20ultrasound%20molecular%20imaging.%20%26lt%3Bi%26gt%3BPhys%20Med%20Biol%26lt%3B%5C%2Fi%26gt%3B%202026.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1088%5C%2F1361-6560%5C%2Fae35c7%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1088%5C%2F1361-6560%5C%2Fae35c7%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Exploiting%20harmonic%20signature%20of%20gas%20vesicles%20in%20amplitude-modulated%20singular%20value%20decomposition%20for%20ultrafast%20ultrasound%20molecular%20imaging%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ge%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henri%22%2C%22lastName%22%3A%22Leroy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nabil%22%2C%22lastName%22%3A%22Haidour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Zucker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Deyver%20Esteban%22%2C%22lastName%22%3A%22Rivera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anatole%22%2C%22lastName%22%3A%22Jimenez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Deffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dina%22%2C%22lastName%22%3A%22Malounda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rohit%22%2C%22lastName%22%3A%22Nayak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Pezet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mathieu%22%2C%22lastName%22%3A%22Pernot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mikhail%20G%22%2C%22lastName%22%3A%22Shapiro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mickael%22%2C%22lastName%22%3A%22Tanter%22%7D%5D%2C%22abstractNote%22%3A%22Objective%3A%20Ultrafast%20nonlinear%20ultrasound%20imaging%20of%20gas%20vesicles%20%28GVs%29%20promises%20high-sensitivity%20biomolecular%20visualization%20for%20applications%20such%20as%20targeted%20molecular%20imaging%20and%20real-time%20tracking%20of%20gene%20expression.%20However%2C%20separating%20GV-specific%20signals%20from%20tissue%20remains%20challenging%20due%20to%20tissue%20clutter%20and%20limitations%20of%20current%20methods%2C%20which%20require%20complex%20transmit%20schemes%20and%20suffer%20from%20incomplete%20tissue%20suppression.%20This%20study%20aims%20to%20develop%20and%20validate%20harmonic%20amplitude-modulated%20singular%20value%20decomposition%20%28HAM-SVD%29%2C%20a%20novel%20technique%20that%20represents%20a%20shift%20from%20current%20GV%20imaging%20methods%20by%20exploiting%20the%20unique%20nonlinear%20pressure-dependence%20of%20the%20GV%20harmonic%20signature.%22%2C%22date%22%3A%222026-01-08%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1088%5C%2F1361-6560%5C%2Fae35c7%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fiopscience.iop.org%5C%2Farticle%5C%2F10.1088%5C%2F1361-6560%5C%2Fae35c7%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220031-9155%2C%201361-6560%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%2294NJIV78%22%5D%2C%22dateModified%22%3A%222026-01-27T12%3A47%3A58Z%22%7D%7D%2C%7B%22key%22%3A%22IERTZCX2%22%2C%22library%22%3A%7B%22id%22%3A4989618%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A804678%2C%22username%22%3A%22j%5Cu00e9r%5Cu00f4me%20baranger%22%2C%22name%22%3A%22%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Fjrme_baranger%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Zhang%20et%20al.%22%2C%22parsedDate%22%3A%222025-04-28%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BZhang%20G%2C%20Vert%20M%2C%20Nouhoum%20M%2C%20Rivera%20E%2C%20Haidour%20N%2C%20Jimenez%20A%2C%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20Amplitude-Modulated%20Singular%20Value%20Decomposition%20for%20Ultrafast%20Ultrasound%20Imaging%20of%20Gas%20Vesicles.%20%26lt%3Bi%26gt%3BIEEE%20Transactions%20on%20Medical%20Imaging%26lt%3B%5C%2Fi%26gt%3B%202025%3B%26lt%3Bb%26gt%3BPP%26lt%3B%5C%2Fb%26gt%3B%3A%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1109%5C%2FTMI.2025.3565023%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1109%5C%2FTMI.2025.3565023%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Amplitude-Modulated%20Singular%20Value%20Decomposition%20for%20Ultrafast%20Ultrasound%20Imaging%20of%20Gas%20Vesicles.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ge%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mathis%22%2C%22lastName%22%3A%22Vert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mohamed%22%2C%22lastName%22%3A%22Nouhoum%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Esteban%22%2C%22lastName%22%3A%22Rivera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nabil%22%2C%22lastName%22%3A%22Haidour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anatole%22%2C%22lastName%22%3A%22Jimenez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Deffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simon%22%2C%22lastName%22%3A%22Barral%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pascal%22%2C%22lastName%22%3A%22Hersen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Pezet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claire%22%2C%22lastName%22%3A%22Rabut%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mikhail%20G%22%2C%22lastName%22%3A%22Shapiro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mickael%22%2C%22lastName%22%3A%22Tanter%22%7D%5D%2C%22abstractNote%22%3A%22Ultrasound%20imaging%20holds%20significant%20promise%20for%20the%20observation%20of%20molecular%20and%20cellular%20phenomena%20through%20the%20utilization%20of%20acoustic%20contrast%20agents%20and%20acoustic%20reporter%20genes.%20Optimizing%20imaging%20methodologies%20for%20enhanced%20detection%20represents%20an%20imperative%20advancement%20in%20this%20field.%20Most%20advanced%20techniques%20relying%20on%20amplitude%20modulation%20schemes%20such%20as%20cross%20amplitude%20modulation%20%28xAM%29%20and%20ultrafast%20amplitude%20modulation%20%28uAM%29%20combined%20with%20Hadamard%20encoded%20multiplane%20wave%20transmissions%20have%20shown%20efficacy%20in%20capturing%20the%20acoustic%20signals%20of%20gas%20vesicles%20%28GVs%29.%20Nonetheless%2C%20uAM%20sequence%20requires%20odd-%20or%20even-element%20transmissions%20leading%20to%20imprecise%20amplitude%20modulation%20emitting%20scheme%2C%20and%20the%20complex%20multiplane%20wave%20transmission%20scheme%20inherently%20yields%20overlong%20pulse%20durations.%20xAM%20sequence%20is%20limited%20in%20terms%20of%20field%20of%20view%20and%20imaging%20depth.%20To%20overcome%20these%20limitations%2C%20we%20introduce%20an%20innovative%20ultrafast%20imaging%20sequence%20called%20amplitude-modulated%20singular%20value%20decomposition%20%28SVD%29%20processing.%20Our%20method%20demonstrates%20a%20contrast%20imaging%20sensitivity%20comparable%20to%20the%20current%20gold-standard%20xAM%20and%20uAM%2C%20while%20requiring%204.8%20times%20fewer%20pulse%20transmissions.%20With%20a%20similar%20number%20of%20transmit%20pulses%2C%20amplitude-modulated%20SVD%20outperforms%20xAM%20and%20uAM%20in%20terms%20of%20an%20improvement%20in%20signal-to-background%20ratio%20of%20%2B%204.78%20%5Cu00b1%200.35%20dB%20and%20%2B%208.29%20%5Cu00b1%203.52%20dB%2C%20respectively.%20Furthermore%2C%20the%20method%20exhibits%20superior%20robustness%20across%20a%20wide%20range%20of%20acoustic%20pressures%20and%20enables%20high-contrast%20imaging%20in%20ex%20vivo%20and%20in%20vivo%20settings.%20Furthermore%2C%20amplitude-modulated%20SVD%20is%20envisioned%20to%20be%20applicable%20for%20the%20detection%20of%20slow%20moving%20microbubbles%20in%20ultrasound%20localization%20microscopy%20%28ULM%29.%22%2C%22date%22%3A%222025-04-28%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1109%5C%2FTMI.2025.3565023%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fresearch.ebsco.com%5C%2Flinkprocessor%5C%2Fplink%3Fid%3Df7e0f525-05ef-3327-b61a-de4bf9ed5ce1%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221558-254X%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2294NJIV78%22%5D%2C%22dateModified%22%3A%222025-11-20T10%3A32%3A38Z%22%7D%7D%2C%7B%22key%22%3A%22C3R3BCJS%22%2C%22library%22%3A%7B%22id%22%3A4989618%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A804678%2C%22username%22%3A%22j%5Cu00e9r%5Cu00f4me%20baranger%22%2C%22name%22%3A%22%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Fjrme_baranger%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Vert%20et%20al.%22%2C%22parsedDate%22%3A%222025-04-08%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BVert%20M%2C%20Zhang%20G%2C%20Bertolo%20A%2C%20Ialy-Radio%20N%2C%20Pezet%20S%2C%20Osmanski%20B%2C%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20Transcranial%20brain-wide%20functional%20ultrasound%20and%20ultrasound%20localization%20microscopy%20in%20mice%20using%20multi-array%20probes.%20%26lt%3Bi%26gt%3BSci%20Rep%26lt%3B%5C%2Fi%26gt%3B%202025%3B%26lt%3Bb%26gt%3B15%26lt%3B%5C%2Fb%26gt%3B%3A12042.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-025-96647-7%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-025-96647-7%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Transcranial%20brain-wide%20functional%20ultrasound%20and%20ultrasound%20localization%20microscopy%20in%20mice%20using%20multi-array%20probes%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mathis%22%2C%22lastName%22%3A%22Vert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ge%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adrien%22%2C%22lastName%22%3A%22Bertolo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%22%2C%22lastName%22%3A%22Ialy-Radio%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Pezet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Osmanski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Deffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mohamed%22%2C%22lastName%22%3A%22Nouhoum%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mickael%22%2C%22lastName%22%3A%22Tanter%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Functional%20ultrasound%20imaging%20%28fUS%29%20and%20ultrasound%20localization%20microscopy%20%28ULM%29%20are%20advanced%20ultrasound%20imaging%20modalities%20for%20assessing%20both%20functional%20and%20anatomical%20characteristics%20of%20the%20brain.%20However%2C%20the%20application%20of%20these%20techniques%20at%20a%20whole-brain%20scale%20has%20been%20limited%20by%20technological%20challenges.%20While%20conventional%20linear%20acoustic%20probes%20provide%20a%20narrow%202D%20field%20of%20view%20and%20matrix%20probes%20lack%20sufficient%20sensitivity%20for%203D%20transcranial%20fUS%2C%20multi-array%20probes%20have%20been%20developed%20to%20combine%20high%20sensitivity%20to%20blood%20flow%20with%20fast%203D%20acquisitions.%20In%20this%20study%2C%20we%20present%20a%20novel%20approach%20for%20the%20combined%20implementation%20of%20transcranial%20whole-brain%20fUS%20and%20ULM%20in%20mice%20using%20a%20motorized%20multi-array%20probe.%20This%20technique%20provides%20high-resolution%2C%20non-invasive%20imaging%20of%20neurovascular%20dynamics%20across%20the%20entire%20brain.%20Our%20findings%20reveal%20a%20significant%20correlation%20between%20absolute%20cerebral%20blood%20volume%20%28%5Cu0394CBV%29%20increases%20and%20microbubble%20speed%2C%20indicating%20vessel-level%20dependency%20of%20the%20evoked%20response.%20However%2C%20the%20lack%20of%20correlation%20with%20relative%20CBV%20%28rCBV%29%20suggests%20that%20fUS%20cannot%20distinguish%20functional%20responses%20alterations%20across%20different%20arterial%20vascular%20compartments.%20This%20methodology%20holds%20promise%20for%20advancing%20our%20understanding%20of%20neurovascular%20coupling%20and%20could%20be%20applied%20in%20brain%20disease%20diagnostics%20and%20therapeutic%20monitoring.%22%2C%22date%22%3A%222025-04-08%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-025-96647-7%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-025-96647-7%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222045-2322%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%2294NJIV78%22%5D%2C%22dateModified%22%3A%222025-06-30T09%3A34%3A19Z%22%7D%7D%2C%7B%22key%22%3A%222G2X7HFX%22%2C%22library%22%3A%7B%22id%22%3A4989618%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A111638%2C%22username%22%3A%22tdeffieux%22%2C%22name%22%3A%22%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Ftdeffieux%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Zhang%20et%20al.%22%2C%22parsedDate%22%3A%222016%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BZhang%20Y%2C%20Tan%20H%2C%20Bertram%20EH%2C%20Aubry%20J-F%2C%20Lopes%20M-B%2C%20Roy%20J%2C%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20Non-Invasive%2C%20Focal%20Disconnection%20of%20Brain%20Circuitry%20Using%20Magnetic%20Resonance-Guided%20Low-Intensity%20Focused%20Ultrasound%20to%20Deliver%20a%20Neurotoxin.%20%26lt%3Bi%26gt%3BUltrasound%20in%20Medicine%20%26amp%3B%20Biology%26lt%3B%5C%2Fi%26gt%3B%202016%3B%26lt%3Bb%26gt%3B42%26lt%3B%5C%2Fb%26gt%3B%3A2261%26%23x2013%3B9.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ultrasmedbio.2016.04.019%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ultrasmedbio.2016.04.019%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Non-Invasive%2C%20Focal%20Disconnection%20of%20Brain%20Circuitry%20Using%20Magnetic%20Resonance-Guided%20Low-Intensity%20Focused%20Ultrasound%20to%20Deliver%20a%20Neurotoxin%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yanrong%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hongying%22%2C%22lastName%22%3A%22Tan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edward%20H.%22%2C%22lastName%22%3A%22Bertram%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Fran%5Cu00e7ois%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria-Beatriz%22%2C%22lastName%22%3A%22Lopes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jack%22%2C%22lastName%22%3A%22Roy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erik%22%2C%22lastName%22%3A%22Dumont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mingxing%22%2C%22lastName%22%3A%22Xie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhiyi%22%2C%22lastName%22%3A%22Zuo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%20L.%22%2C%22lastName%22%3A%22Klibanov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kevin%20S.%22%2C%22lastName%22%3A%22Lee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Max%22%2C%22lastName%22%3A%22Wintermark%22%7D%5D%2C%22abstractNote%22%3A%22Disturbances%20in%20the%20function%20of%20neuronal%20circuitry%20contribute%20to%20most%20neurologic%20disorders.%20As%20knowledge%20of%20the%20brain%5Cu2019s%20connectome%20continues%20to%20improve%2C%20a%20more%20re%5Cufb01ned%20understanding%20of%20the%20role%20of%20speci%5Cufb01c%20circuits%20in%20pathologic%20states%20will%20also%20evolve.%20Tools%20capable%20of%20manipulating%20identi%5Cufb01ed%20circuits%20in%20a%20targeted%20and%20restricted%20manner%20will%20be%20essential%20not%20only%20to%20expand%20our%20understanding%20of%20the%20functional%20roles%20of%20such%20circuits%2C%20but%20also%20to%20therapeutically%20disconnect%20critical%20pathways%20contributing%20to%20neurologic%20disease.%20This%20study%20took%20advantage%20of%20the%20ability%20of%20low-intensity%20focused%20ultrasound%20%28FUS%29%20to%20transiently%20disrupt%20the%20blood%5Cu2013brain%20barrier%20%28BBB%29%20to%20deliver%20a%20neurotoxin%20with%20poor%20BBB%20permeability%20%28quinolinic%20acid%20%5BQA%5D%29%20in%20a%20guided%20manner%20to%20a%20target%20region%20in%20the%20brain%20parenchyma.%20Ten%20male%20Sprague-Dawley%20rats%20were%20divided%20into%20two%20groups%20receiving%20the%20following%20treatments%3A%20%28i%29%20magnetic%20resonance-guided%20FUS%201%20microbubbles%201%20saline%20%28n%205%205%29%2C%20or%20%28ii%29%20magnetic%20resonance%5Cu2013guided%20FUS%201%20microbubbles%201%20QA%20%28n%205%205%29.%20Systemic%20administration%20of%20QA%20was%20well%20tolerated.%20However%2C%20when%20QA%20and%20microbubbles%20were%20systemically%20administered%20in%20conjunction%20with%20magnetic%20resonance-guided%20FUS%2C%20the%20BBB%20was%20disrupted%20and%20primary%20neurons%20were%20destroyed%20in%20the%20targeted%20subregion%20of%20the%20hippocampus%20in%20all%20QA-treated%20animals.%20Administration%20of%20vehicle%20%28saline%29%20together%20with%20microbubbles%20and%20FUS%20also%20disrupted%20the%20BBB%20but%20did%20not%20produce%20neuronal%20injury.%20These%20%5Cufb01ndings%20indicate%20the%20feasibility%20of%20non-invasively%20destroying%20a%20targeted%20region%20of%20the%20brain%20parenchyma%20using%20low-intensity%20FUS%20together%20with%20systemic%20administration%20of%20microbubbles%20and%20a%20neurotoxin.%20This%20approach%20could%20be%20of%20therapeutic%20value%20in%20various%20disorders%20in%20which%20disturbances%20of%20neural%20circuitry%20contribute%20to%20neurologic%20disease.%20%28E-mail%3A%20Max.Wintermark%40gmail.com%20and%20ksl3h%40virginia.%20edu%29%20%5Cu00d3%202016%20World%20Federation%20for%20Ultrasound%20in%20Medicine%20%26amp%3B%20Biology.%22%2C%22date%22%3A%2209%5C%2F2016%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.ultrasmedbio.2016.04.019%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS0301562916300564%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%2203015629%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%2294NJIV78%22%5D%2C%22dateModified%22%3A%222025-11-20T10%3A32%3A33Z%22%7D%7D%2C%7B%22key%22%3A%225TIMJDF2%22%2C%22library%22%3A%7B%22id%22%3A4989618%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A111638%2C%22username%22%3A%22tdeffieux%22%2C%22name%22%3A%22%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Ftdeffieux%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Zhang%20et%20al.%22%2C%22parsedDate%22%3A%222015%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B1%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BZhang%20Y%2C%20Aubry%20J-F%2C%20Zhang%20J%2C%20Wang%20Y%2C%20Roy%20J%2C%20Mata%20JF%2C%20%26lt%3Bi%26gt%3Bet%20al.%26lt%3B%5C%2Fi%26gt%3B%20Defining%20the%20Optimal%20Age%20for%20Focal%20Lesioning%20in%20a%20Rat%20Model%20of%20Transcranial%20HIFU.%20%26lt%3Bi%26gt%3BUltrasound%20in%20Medicine%20%26amp%3B%20Biology%26lt%3B%5C%2Fi%26gt%3B%202015%3B%26lt%3Bb%26gt%3B41%26lt%3B%5C%2Fb%26gt%3B%3A449%26%23x2013%3B55.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ultrasmedbio.2014.09.029%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ultrasmedbio.2014.09.029%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Defining%20the%20Optimal%20Age%20for%20Focal%20Lesioning%20in%20a%20Rat%20Model%20of%20Transcranial%20HIFU%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yanrong%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Fran%5Cu00e7ois%22%2C%22lastName%22%3A%22Aubry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Junfeng%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yi%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jack%22%2C%22lastName%22%3A%22Roy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jaime%20F.%22%2C%22lastName%22%3A%22Mata%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wilson%22%2C%22lastName%22%3A%22Miller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erik%22%2C%22lastName%22%3A%22Dumont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mingxing%22%2C%22lastName%22%3A%22Xie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kevin%22%2C%22lastName%22%3A%22Lee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhiyi%22%2C%22lastName%22%3A%22Zuo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Max%22%2C%22lastName%22%3A%22Wintermark%22%7D%5D%2C%22abstractNote%22%3A%22This%20study%20aimed%20at%20determining%20the%20optimal%20age%20group%20for%20high-intensity%20focused%20ultrasound%20%28HIFU%29%20experiments%20for%20producing%20lesions%20in%20rats.%20Younger%20rats%20have%20thinner%20skulls%2C%20allowing%20for%20the%20acoustic%20waves%20to%20propagate%20easily%20through%20the%20skull%20without%20causing%20burns%20of%20the%20skin%20and%20brain%20surface.%20Younger%20rats%20however%2C%20have%20a%20smaller%20brain%20that%20can%20make%20HIFU%20focusing%20in%20the%20brain%20parenchyma%20challenging%20because%20of%20the%20focus%20size.%20In%20this%20study%2C%20we%20conducted%20transcranial%20HIFU%20sonications%20in%20rat%20pups%20of%20different%20ages%20%28from%209%20to%2043%20d%29%20with%20a%201.5MHz%20MR%20compatible%20transducer.%20The%20electric%20power%20was%20selected%20to%20always%20reach%20a%20target%20temperature%20of%20at%20least%2050%20C%20in%20the%20parenchyma.%20The%20thickness%20of%20the%20skull%20and%20of%20the%20brain%20parenchyma%20was%20measured%20using%20T2weighted%20MR%20imaging.%20Results%20showed%20that%20the%20thickness%20of%20the%20brain%20parenchyma%20increased%20quickly%20from%20P9%20to%20P12%2C%20reaching%208.5%20mm%20at%20P16%2C%20and%20then%20increasing%20gradually%20along%20with%20age.%20The%20skull%20thickness%20increased%20gradually%20from%20P9%20to%20P26%2C%20and%20then%20more%20quickly%20after%20P30.%20The%20ratio%20between%20brain%20parenchyma%20thickness%20and%20skull%20thickness%20decreased%20gradually%20with%20age.%20For%20the%20pups%20at%2030%20d%2C%20the%20temperature%20in%20the%20brain%20tissue%20adjacent%20to%20the%20skull%20increased%20to%2048.9%20C%2C%20and%20those%20from%20the%20rodents%20older%20than%2033%20d%20reached%2060%20C%20or%20higher%2C%20which%20can%20produce%20undesired%20irreversible%20damage%20in%20this%20location.%20We%20conclude%20that%20young%20rats%20aged%2016%5Cu201326%20d%20are%20optimal%20for%20experiments%20producing%20transcranial%20HIFU%20lesions%20in%20rats%20with%20an%20intact%20skull.%20%28E-mail%3A%20Max.Wintermark%40gmail.%20com%29%20%5Cu00d3%202015%20World%20Federation%20for%20Ultrasound%20in%20Medicine%20%26amp%3B%20Biology.%22%2C%22date%22%3A%2202%5C%2F2015%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.ultrasmedbio.2014.09.029%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS0301562914006474%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%2203015629%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%2294NJIV78%22%5D%2C%22dateModified%22%3A%222025-11-20T10%3A32%3A29Z%22%7D%7D%5D%7D
1
Zhang G, Leroy H, Haidour N, Zucker N, Rivera DE, Jimenez A, et al. Exploiting harmonic signature of gas vesicles in amplitude-modulated singular value decomposition for ultrafast ultrasound molecular imaging. Phys Med Biol 2026. https://doi.org/10.1088/1361-6560/ae35c7.
1
Zhang G, Vert M, Nouhoum M, Rivera E, Haidour N, Jimenez A, et al. Amplitude-Modulated Singular Value Decomposition for Ultrafast Ultrasound Imaging of Gas Vesicles. IEEE Transactions on Medical Imaging 2025;PP: https://doi.org/10.1109/TMI.2025.3565023.
1
Vert M, Zhang G, Bertolo A, Ialy-Radio N, Pezet S, Osmanski B, et al. Transcranial brain-wide functional ultrasound and ultrasound localization microscopy in mice using multi-array probes. Sci Rep 2025;15:12042. https://doi.org/10.1038/s41598-025-96647-7.
1
Zhang Y, Tan H, Bertram EH, Aubry J-F, Lopes M-B, Roy J, et al. Non-Invasive, Focal Disconnection of Brain Circuitry Using Magnetic Resonance-Guided Low-Intensity Focused Ultrasound to Deliver a Neurotoxin. Ultrasound in Medicine & Biology 2016;42:2261–9. https://doi.org/10.1016/j.ultrasmedbio.2016.04.019.
1
Zhang Y, Aubry J-F, Zhang J, Wang Y, Roy J, Mata JF, et al. Defining the Optimal Age for Focal Lesioning in a Rat Model of Transcranial HIFU. Ultrasound in Medicine & Biology 2015;41:449–55. https://doi.org/10.1016/j.ultrasmedbio.2014.09.029.