This weekly seminar aims at gathering researchers from different fields (physicists, chemists and biologists) and from different institutes in central Paris. The objective is to cover a broad interface between physics, chemistry and biology, including experimental, numerical and/or theoretical approaches. To describe life sciences all scales are needed, from single molecules, to cells, tissues, organs, organisms, and populations. The scope of our seminar encompasses embryonic development, genetic regulation, evolution, biomechanics and cell migration, immunology, microbiology, synthetic biology, etc.

The seminar usually takes place on Fridays, at 1pm, in Salle Favard, IBENS, 46 rue d’Ulm, 75005 Paris.

It is jointly organized by António Carlos Costa, Raphaël Janneret (LPENS) and Philippe Marcq (PMMH, ESPCI).

4 February 2022, 1PM

Pierre Ronceray (Centuri – on Zoom)

What can we learn from the stochastic trajectories of biological systems?

Stochastic differential equations are often used to model the dynamics of living systems, from Brownian motion at the molecular scale to the dynamics of cells and animals. How does one learn such models from experimental data? This task faces multiple challenges, from information-theoretical limitations to practical considerations. I will  present a recent and ongoing effort to develop new methods to reconstruct such stochastic dynamical models from  experimental data, with a focus on robustness and data efficiency. This provides a generic means to quantify complex behavior and unfold the underlying mechanisms of an apparently erratic trajectory.