Functional ultrasound imaging

Neurofunctional ultrasound imaging: a new paradigm for neurosciences

Ultrasound is entering the world of neurosciences with the use of ultrasensitive Doppler techniques to detect small blood flow variations induced by neuronal activation. With neurofunctional ultrasound imaging, the brain activity can be imaged with an excellent spatio-temporal resolution and an exquisite sensitivity, embedded in portable bedside systems. We have received an ERC Advanced Grant FUSIMAGINE to develop this disruptive imaging modality.

Main publications:

[1] Deffieux T, Demene C, Pernot M, Tanter M. Functional ultrasound neuroimaging: a review of the preclinical and clinical state of the art. Curr Opin Neurobiol (2018) 50:128–135. doi.org/10.1016/j.conb.2018.02.001

[2] Demene C, Baranger J, Bernal M, Delanoe C, Auvin S, Biran V, Alison M, Mairesse J, Harribaud E, Pernot M, et al. Functional ultrasound imaging of brain activity in human newborns. Sci Transl Med (2017) 9: doi.org/10.1126/scitranslmed.aah6756

[3] Macé E, Montaldo G, Cohen I, Baulac M, Fink M, Tanter M. Functional ultrasound imaging of the brain. Nat Methods (2011) 8:662–664. doi.org/10.1038/NMETH.1641

 

3D ultrafast and multiparametric imaging of the heart functions

We have built the very first prototype for 3D ultrafast ultrasound imaging, capable of imaging the human heart at several thousands of frames per second, and to quantify a complete set of functional parameters: the myocardium contractility, the electrical activation and the blood flow can be recorded during a single heartbeat. These data will ultimately strengthen the diagnosis of many cardiovascular diseases. Early developments have been funded by the ERC Starting Grant ULTRAECHOCARDIO.

Main publications:

[1] Provost J, Papadacci C, Arango JE, Imbault M, Fink M, Gennisson J-L, Tanter M, Pernot M. 3D ultrafast ultrasound imaging in vivo. Phys Med Biol (2014) 59:L1–L13. doi.org/10.1088/0031-9155/59/19/L1

[2] Papadacci C, Pernot M, Couade M, Fink M, Tanter M. High-contrast ultrafast imaging of the heart. IEEE Trans Ultrason Ferroelectr Freq Control (2014) 61:288–301. doi.org/10.1109/TUFFC.2014.2909

SCIENTIFIC LEADER
Thomas Deffieux

 

KEYWORDS
  • 3D ultrafast ultrasound imaging for cardiac applications
  • functional ultrasound imaging of the brain
  • PET-ultrasound imaging